Dosing CBD

The following paraphrases an article written on cannabis dosing by Martin A. Lee on May 16th, 2017 located on the Project CBD website.  We have paraphrased this information to cover only the CBD related information for you.

Cbd DOSING 101

High dose?  Low dose? CBD?  Optimizing one’s therapeutic use of CBD may entail some experimentation.  In summary, the goal is to administer consistent, measurable doses of a CBD remedy to obtain the desired therapeutic effect.

 

CBD can be effective therapeutically at a wide range of doses. There’s no standard dosage that’s right for everyone. Here are some do’s and don’ts for dosing:

  • Figuring out the optimal dose of CBD will involve some trial and error. CBD oil is available in many different forms (oil, blends, gummies, gel caps, etc.).
  • Cannabidiol (CBD) does not cause a psychoactive high like THC. High doses of CBD-rich formulations are safe, well tolerated.
  • Preclinical studies have shown that full-spectrum CBD-rich cannabis oil (with less than .3% THC) is effectual at much lower doses and has a much wider therapeutic window than pure, pharmaceutical-grade CBD.
  • For cannabis-inexperienced patients, it is best to start with low doses of a CBD-rich remedy and increase the dose over a week or two until the desired therapeutic effect has been reached.

“It’s no longer a question whether marijuana has medical value. Now it’s about figuring out how to optimize one’s therapeutic use of cannabis. That can be a challenge – for doctors as well as patients. Most physicians never learned about cannabis in medical school and, according to a 2017 survey, few feel they are qualified to counsel patients about dosage, CBD:THC ratios, different modes of administration, and potential side effects.

“Dosing cannabis is unlike any therapeutic agent to which I was exposed in my medical training,” says Dustin Sulak, D.O., the director of Integr8 Health, which serves patients at offices in Maine and Massachusetts. “Some patients effectively use tiny amounts of cannabis, while others use incredibly high doses. I’ve seen adult patients achieve therapeutic effects at 1 mg of total cannabinoids daily, while others consume over 2000 mgs daily without adverse effects.”

Cannabis comes in many different forms with a wide range of potencies, and its production and distribution have yet to be standardized in states where cannabis is legal for therapeutic use. So what’s the best way to proceed when it seems like cannabis dosing is all over the map?

Broadly speaking, there are three types of resin-rich cannabis (and cannabis products):

  • Type 1 (THC-dominant) – High THC, low CBD (ubiquitous psychoactive marijuana varietals that millions like to smoke)
  • Type 2 (THC & CBD) – Mixed THC and CBD cultivars (psychoactive, but not as edgy as THC-dominant varietals)
  • Type 3 (CBD-dominant) – High CBD, low THC (non-euphoric marijuana or hemp)

There’s also a fourth type – those rare cannabis cultivars that prominently express a so-called minor cannabinoid (like CBG or THCV). But in terms of what’s currently available for patients, the THC:CBD ratio is paramount and must be considered when formulating dosage strategies.”  Direct quote from Martin A. Lee, May 16, 2017, ProjectCBD.com .

“High dose CBD therapy is another way of healing without the high.

As a general rule, Type 3 CBD-dominant cannabis (with little THC) won’t make a person feel stoned. Nor will a pure CBD isolate (with no THC). But CBD isolates lack critical aromatic terpenes and other cannabinoids, which interact synergistically to enhance CBD’s therapeutic benefits. Single molecule cannabinoids are simply not as versatile or as effective as whole plant formulations.

Preclinical research indicates that full spectrum CBD-rich cannabis oil is effective at much lower doses and has a wider therapeutic window than a CBD isolate. “The therapeutic synergy observed with plant extracts results in the requirement for a lower amount of active components, with consequent reduced adverse side effects,” a 2015 Israeli study concluded.

In animal studies, CBD isolates require very high – and precise – doses to be effective. Problematic drug interactions are also more likely with a high-dose CBD isolate than with whole plant cannabis.” Direct quote from Martin A. Lee, May 16, 2017, ProjectCBD.com .

CBD dosing should be individually determined for people and pets. Many factors can affect dosage requirements which are influenced by one’s overall health, diet, exercise, sleep patterns, day-to-day stress, and genetics. CBD is best used as part of a healthy lifestyle as one can have