THCH (Tetrahydrocannabihexol): A Comprehensive Analysis

Tetrahydrocannabihexol (THCH): A Comprehensive Analysis

In the ever-evolving world of cannabis research, new cannabinoids are being discovered and studied, each with their unique properties and potential benefits. One such cannabinoid that has recently caught the attention of researchers and enthusiasts alike is Tetrahydrocannabihexol, commonly known as THCH. In this article, our team aims to provide a comprehensive analysis of THCH, its discovery, chemical structure, potential effects, and the current state of research surrounding this intriguing compound.

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    Discovery and Chemical Structure of THCH

    The discovery of Tetrahydrocannabihexol (THCH) is a significant milestone in the field of cannabis research. This compound was first isolated from the cannabis plant in 2020 by an Italian team of researchers. The team was led by Dr. Cinzia Citti, a leading researcher in the field of analytical chemistry and cannabis research, and the discovery was published in the scientific journal “Nature” [1].

    THCH is a hexyl homologue of THC, meaning its molecular structure is identical to THC but arranged differently. This unique arrangement is what makes THCH intriguing and a subject of ongoing research.

    Discovery of THCH Overview

    Discovery Detail Description
    Year of Discovery 2020
    Research Team Italian team led by Dr. Cinzia Citti
    Published In Nature & Cayman Chem
    Chemical Structure Hexyl homologue of THC
    Fig.1 - Chemical Structure of THCH

    Psychoactive Properties and Potential Effects of THCH

    Like THC, THCH is a psychoactive compound. This means it has the potential to alter one’s consciousness or mood. However, the intensity and nature of these psychoactive effects are where THCH stands out.

    Anecdotal evidence suggests that the psychoactive effects of THCH are profound, often described as a deeply euphoric and relaxing sensation [2]. Some users have reported that the effects of THCH last longer than those of other psychoactive cannabinoids, potentially twice as long. However, these claims are based on user reports and have not yet been confirmed by scientific studies.

    Current Research on THCH

    The potential medical benefits of THCH are currently a subject of speculation and ongoing research. Anecdotal evidence suggests potential benefits for conditions such as pain, sleep insomnia, and anxiety. However, these claims are not yet supported by scientific research.

    It’s important to note that the discovery of THCH is still recent, and comprehensive studies on its potential therapeutic uses are yet to be conducted. Therefore, while the anecdotal evidence is promising, it’s crucial to approach these claims with a healthy dose of skepticism until more research is conducted.


    Legal Disclaimer

    The information provided on this website, including information regarding THCH and other cannabinoids, is based on preliminary research, anecdotal evidence, and personal testimonials. It is not intended as, and should not be understood as, a substitute for professional medical advice, diagnosis, or treatment.

    None of the potential benefits listed on this website have been evaluated or approved by the Food and Drug Administration or any other national or international health organization. The products sold on this website are not intended to diagnose, treat, cure, or prevent any disease.

    Before starting any new treatment or supplement, including those containing THCH or other cannabinoids, please consult with a healthcare provider. Do not disregard professional medical advice or delay seeking it because of something you have read on this website.

    Potential Effects of THCH

    Effect Intensity
    Pain Relief
    Sleep Aid
    Anxiety Relief
    Potential Benefits Current Evidence
    Pain Relief Anecdotal
    Sleep Aid Anecdotal
    Anxiety Relief Anecdotal

    Stats: Complete Scientific Overview of THCH

    Technical Information
    Formal Name (6aR,10aR)-3-hexyl-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol
    CAS Number 20622-30-4
    Molecular Formula C22H32O2
    Formula Weight 328.5
    SMILES CC1=CC[C@](C(C)(C)OC2=C3C(O)=CC(CCCCCC)=C2)([H])[C@@]3([H])C1
    InChi Code InChI=1S/C22H32O2/c1-5-6-7-8-9-16-13-19(23)21-17-12-15(2)10-11-18(17)22(3,4)24-20(21)14-16/h10,13-14,17-18,23H,5-9,11-12H2,1-4H3/t17-,18-/m1/s1
    Regulatory Information
    DEA Exempt Notification This product is a DEA exempt preparation of a scheduled compound - does not require DEA Controlled Substance registration or DEA 222 form. For alternate sizes please contact sales.
    Shipping & Storage Information
    Optimal Storage -20°C
    Stability ≥ 1 year

    To better understand the anecdotal evidence provided, here is a brief summary:

    • High Times: Anecdotal evidence suggests that the psychoactive effects of THCH are profound, often described as a deeply euphoric and relaxing sensation. Some users have reported that the effects of THCH last longer than those of other psychoactive cannabinoids, potentially twice as long.
    • Preliminary reports suggest that THCH might help elevate mood and make users happier. Some users have reported feelings of joy, euphoria, relaxation, and pain relief.

    It’s important to note that anecdotal evidence is based on personal experiences and reports from users, and while it can provide valuable insights, it’s not a substitute for rigorous scientific research. More research is needed to confirm these claims and fully understand the properties and effects of THCH.

    Is THCH Natural or Synthetic?

    Tetrahydrocannabihexol (THCH) is a naturally occurring cannabinoid found in the cannabis plant. Like other cannabinoids, it is produced in the plant’s trichomes, which are tiny, hair-like structures on the plant’s surface. These trichomes serve as the plant’s defense mechanism against herbivores and environmental stressors, and they are also the primary site of cannabinoid and terpene synthesis.

    The production of cannabinoids like THCH in the cannabis plant is a complex process that involves several enzymatic reactions. The process begins with the synthesis of a compound called geranyl pyrophosphate and olivetolic acid, which combine to form cannabigerolic acid (CBGA), the precursor to all cannabinoids. Specific enzymes then convert CBGA into the acidic forms of THC, CBD, and other cannabinoids. These acidic forms are then decarboxylated, often through heat or aging, to produce the cannabinoids we are familiar with, such as THC, CBD, and in this case, THCH.

    The reason why THCH and other cannabinoids are produced by the cannabis plant is not entirely understood, but it’s believed to be part of the plant’s defense mechanism. Cannabinoids have been found to have antimicrobial properties, and they may help protect the plant against insect pests and other herbivores. Some researchers also believe that cannabinoids may help the plant to resist environmental stresses and may play a role in the plant’s communication with other plants and organisms.

    However, the presence of THCH in the cannabis plant is relatively rare and occurs in much smaller concentrations compared to more well-known cannabinoids like THC and CBD. This is likely due to the specific enzymes needed to produce THCH being less common or less active in the plant.

    It’s also important to note that the specific strains of cannabis, growing conditions, and harvesting and curing processes can all influence the levels of different cannabinoids in the plant, including THCH.

    While we have a basic understanding of how THCH is produced in the cannabis plant, more research is needed to fully understand why it’s produced and what factors influence its production. As our understanding of cannabis and its many cannabinoids continues to grow, we may be able to uncover new ways to optimize the production of cannabinoids like THCH and harness their potential benefits.

    Legal Status and Availability of THCH

    According to federal law, THCH is a legal cannabinoid as long as it comes from the hemp plant. This is because it’s protected under the 2018 Farm Bill, which states that all hemp derivatives are legal as long as they contain no more than 0.3% Delta 9 THC bydry weight [3].

    THCH Closing Thoughts

    The discovery of THCH has added another layer of complexity to our understanding of the cannabis plant and its potential benefits. While the anecdotal evidence surrounding the effects of THCH is promising, more research is needed to confirm these claims and fully understand the properties of this cannabinoid.

    As we continue to explore the world of cannabinoids, it’s essential to approach new discoveries like THCH with an open mind and a commitment to rigorous scientific inquiry. Only through comprehensive research can we truly unlock the potential of these fascinating compounds and understand their full impact on  health and well-being.

    Keywords: THCH, Tetrahydrocannabihexol, cannabinoid, cannabis research, psychoactive compound, medical potential, legal status, hemp plant, 2018 Farm Bill, THC, CBD, molecular structure, effects of THCH, potential benefits, scientific research, anecdotal evidence.


    1. Nature: A new phytocannabinoid
    2. High Times: THCH – Everything There is to Know
    3. 2018 Farm Bill
    4. Cayman Chem
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